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At the time of writing (October of 2021), InDesign does not support typesetting Manichaean Avestan script: the script it is not recognized as a right-to-left script and therefore , Manichaean text becomes corrupt Avestan text is garbled when rendered in InDesign (both in the native Adobe text renderer Lipika and InDesign’s version of HarfBuzz). Only TeX can be tweaked to render Manichaean the Avestan script correctly, and therefore, Manichaean text which means that Avestan text in the Avestan script can and must only be typeset by TAT, who use an installation of LuaTeX. 

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See Web Fonts and Script Proportions on Brill Websites 034 XXX for web font, font license and font rights holder information; script and language tag and script proportion.